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Previous association studies have identified variants on 2q35 associated with the risk of breast cancer.

1 × 10 −19) and identify 13 additional linked variants ( r 2 0 8) in the 20Kb linkage block containing the enCNV ( P = 3.. The enCNV is correlated with modified ERα binding and monoallelic-repression of IGFBP5 following oestrogen treatment.. We report a novel intergenic breast cancer risk locus containing an enhancer copy number variation (enCNV; deletion) located approximately 400Kb upstream to IGFBP5, which overlaps an intergenic ERα-bound enhancer that loops to the IGFBP5 promoter.. 2 × 10 −15 − 5 6 × 10 −17). Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females.

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We report a dose-dependent inverse association of 2q35 enCNV genotype (percopy OR = 0.. We investigated the association of enCNV genotype with breast cancer in 1,182 cases and 1,362 controls, and replicate our findings in an independent set of 62,533 cases and 60,966 controls from 41 case control studies and 11 GWAS.. To identify functional susceptibility loci for breast cancer, we interrogated the 2q35 gene desert for chromatin architecture and functional variation correlated with gene expression.. 68 95%CI 0 55–0 83, P = 0 0002; replication OR = 0 77 95% CI 0 73-0 82, P = 2. Download Ek Paheli Leela Full Movie Mp4 Hd

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